AN UNBIASED VIEW OF JNJ-632

[61] demonstrated that the CRISPR/Cas9 technique could specially focus on and cleave conserved areas from the HBV genome, leading to sturdy suppression of viral gene expression and replication the two in vitro and in vivoThey observed that Cas9-mediated base editing is a possible strategy to heal CHB by permanently inactivating built-in HBV DNA and